2025
(68) Ohta, M.; Okuda, A.; Takahashi, K.; Hosoya, S.; Yoshigoe, Y.; Saito, S.
Synthesis and Properties of [3]Rotaxanes with Two Oligo(para-phenylene) Axles.
Chem. Eur. J. 2025, 31(25), e202500522
Selected as Very Important Paper and Editors' Choice
2024
(67) Saito, S.; Koizumi, Y.; Ito, Y.; Yasuda, T.; Yoshigoe, Y.
Platinum-Catalyzed Diboration of Alkynes by 1,8-Diaminonaphthalene-Protected Diboronic Acid (B2(dan)2).
J. Org. Chem. 2024, 89(22), 16947-16951
(66) Yoshigoe, Y.; Shimada, H.; Takaki, T.; Imai, Y.; Saito, S.
Synthesis and Isolation of a Homochiral Nanohoop Composed of a Tröger's Base and Hexaparaphenylene.
Chem. Eur. J. 2024, e202304059
CLICK HERE! Selected as the Cover Picture
(65) Ohta, M.; Okuda, A.; Hosoya, S.; Yoshigoe, Y.; Saito, S.
Synthesis of Interlocked and Non-Interlocked Deca(para-phenylene) Derivatives by Ni-mediated Biaryl Coupling.
Chem. Eur. J. 2024, e202304309
Selected as the Hot Paper
2023
(64) Yasuda, T.; Yoshigoe, Y.; Saito, S. Copper-Catalyzed Borylation of Styrenes by 1,8-Diaminonaphthalene-Protected Diboronic Acid.
Org. Lett. 2023, 25(12), 2093-2097
CLICK HERE! Highlighted in Organic Chemistry Portal
(63) Rashid, S.; Murakami, T.; Koganezawa, H.; Yoshigoe, Y.; Hosoya, S.; Saito, S. Fluorinated [2]rotaxanes with spirofluorene motifs: a non-symmetric distribution of the ring component along the axle component.
New J. Chem. 2023, 47(2), 900-909
2022
(62) Yoshigoe, Y.; Hashizume, K.; Saito, S. Synthesis and stereochemistry of chiral aza-boraspirobifluorenes with tetrahedral boron-stereogenic centers.";
Dalton Trans. 2022, 51(44), 17035-17039
(61) Yoshigoe, Y.; Tanji, Y.; Hata, Y.; Osakada, K.; Saito, S.; Kayahara, E.; Yamago, S.; Tsuchido, Y.; Kawai, H. Dynamic Au–C σ-Bonds Leading to an Efficient Synthesis of [n]Cycloparaphenylenes (n = 9–15) by Self-Assembly.";
JACS Au 2022, 2(8), 1857-1868
(60) Kawasaki, Y.; Rashid, S.; Ikeyatsu, K.; Mutoh, Y.; Yoshigoe, Y.; Kikkawa, S.; Azumaya, I.; Hosoya, S.; Saito, S. "Conformational Control of [2]Rotaxane by Hydrogen Bond.";
J. Org. Chem. 2022, 87(9), 5744-5759
2021
(59) Saito, S.; Katamura, T.; Tsukazaki, R.; Fujisawa, A.; Yoshigoe, Y.; Mutoh, Y., "The Aza-Prins Reaction of 1,2-Dicarbonyl Compounds with 3-Vinyltetrahydroquinolines: Application to the Synthesis of Polycyclic Spirooxindole Derivatives.";
J. Org. Chem. 2021, 86(23), 16425-16433
2020
(58) A. Suzuki, Y. Mutoh, N. Tsuchida, C.-W. Fung, S. Kikkawa, I. Azumaya and S. Saito, "Synthesis and Systematic Structural Analysis of Cationic Half-Sandwich Ruthenium Charcogenocarbonyl Complexes.";
Chem.- Eur. J. 2020, 26(17), 3795-3802
(57) Y. Yamazaki, R. Mizuma, H. Abe, R. Aoki, Y. Mutoh, and S. Saito, "Synthesis of Helical 3,3′-Bridged-2,2′-bibenzo[g]quinolines";
Chem. Lett. 2020, 49, 133-136
(56) T. Watanabe, Y. Mutoh, and S. Saito, "Synthesis of lactone-fused pyrroles by ruthenium-catalyzed 1,2-carbon migration-cycloisomerization";
Org. Biomol. Chem. 2020, 18, 81-85
(55) Y. Mutoh, K. Yamamoto, and S. Saito, "Suzuki–Miyaura Cross-Coupling of 1,8-Diaminonaphthalene (dan)-Protected Arylboronic Acids";
ACS Catalysis 2020, 10, 352-357.
CLICK HERE! Selected as the Cover Picture
(54) C.-W. Fung, G. Fukada, Y. Mutoh, N. Tsuchida, and S. Saito, "Synthesis and properties of anionic ruthenium thionitrosyl and selenonitrosyl complexes that contain tetraanionic 2-hydroxybenzamidobenzene ligands";
Dalton Transactions 2020, 49, 613-624.
CLICK HERE! Selected as the Cover Picture
2019
(53) K. Yamamoto, Y. Mohara, Y. Mutoh, S. Saito, “Ruthenium-Catalyzed (Z)-Selective Hydroboration of Terminal Alkynes with Naphthalene-1,8-diaminatoborane.” ;
J. Am. Chem. Soc. 2019, 141, 17042-17047.
CLICK HERE! Selected as the Cover Picture
(52) Y. Yamashita, Y. Saito, S. Kikkawa, Y. Mutoh, S. Hosoya, I. Azumaya S. Saito, “Evaluation of the Steric Bulk of Substituents Utilizing the Shuttling Behavior of [2]Rotaxanes with N-Arylpyrrole Moieties” ;
Eur. J. Org. Chem. 2019, 21, 3412-3420.
CLICK HERE! Selected as the Cover Picture
2018
(51) T. Watanabe, H. Abe, Y. Mutoh, S. Saito, “Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylstyrenes via 1,2-Carbon Migration That Leads to Substituted Naphthalenes.” ;
Chem. Eur. J. 2018, 24(45), 11545-11549.
CLICK HERE! Selected as the Cover Picture
2017
(50) Y. Mutoh, Y. Mohara, S. Saito, "(Z)-Selective Hydrosilylation of Terminal Alkynes with HSiMe(OSiMe3)2 Catalyzed by a Ruthenium Complex Containing an N-Heterocyclic Carbene";
Org. Lett. 2017, 19, 5204-5207.
(49) Y. Mochizuki, K. Ikeyatsu, Y. Mutoh, S. Hosoya, S. Saito, “Synthesis of Mechanically Planar Chiral rac-[2]Rotaxanes by Partitioning of an Achiral [2]Rotaxane: Stereoinversion Induced by Shuttling”;
Org. Lett. 2017, 19(16), 4347-4350.
(48) K. Ito, Y. Mutoh, S. Saito, “Synthesis of [2]Catenanes by Intramolecular Sonogashira-Type Reaction”;
J. Org. Chem. 2017, 82(12), 6118-6124.
(47) T. Watanabe, Y. Mutoh, S. Saito, “Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration”;
J. Am. Chem. Soc. 2017, 139(23), 7749-7752.
(46) T. Katamura, T. Shimizu, Y. Mutoh, S. Saito, “Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction”;
Org. Lett. 2017, 19, 266-269.
(45) A. Suzuki, T. Arai, K. Ikenaga, Y. Mutoh, N. Tsuchida, S. Saito, Y. Ishii, "A ruthenium tellurocarbonyl (CTe) complex with a cyclopentadienyl ligand: systematic studies of a series of chalcogenocarbonyl complexes [CpRuCl(CE)(H2IMes)] (E = O, S, Se, Te)" ;
Dalton Trans. 2017, 46(1), 44-48.
2016
(44) Y. Matsuoka, Y. Mutoh, T. Kasama, I. Azumaya, S. Kikkawa, T. Kasama, S. Saito, “Synthesis and Shuttling Behavior of [2]Rotaxanes with a Pyrrole Moiety” ;
J. Org. Chem. 2016, 3479–3487. (ACS Editors' Choice and Featured Article)
CLICK HERE! Selected as the Front Cover
(43) R. Hayashi, P. Slavik, Y. Mutoh, T. Kasama, S. Saito, “Sequence-Selective Synthesis of Rotacatenane Isomers” ;
J. Org. Chem. 2016, 81, 1175-1184.
2015
(42) S. Saito, Y. Hirano, Y. Mutoh, T. Kasama, “Synthesis of a Homochiral [2]Rotaxane from a BINOL-derived Macrocyclic Phenanthroline” ;
Chem. Lett. 2015, 44, 1509-1511.
(41) R. Hayashi, Y. Mutoh, T. Kasama, S. Saito, “Synthesis of [3]Rotaxanes by the Combination of Copper-Mediated Coupling Reaction and Metal-Template Approach” ;
J. Org. Chem. 2015, 80, 7536-7546.
(40) S. Saito, T. Ohkubo, Y. Yamazaki, T. Yokoyama, Y. Mutoh, R. Yamasaki, T. Kasama, “Macrocyclic Phenanthroline-Copper Complex with Less Steric Hindrance: Synthesis, Structure, and Application to the Synthesis of a [2]Rotaxane.” ;
Bull. Chem. Soc. Jpn. 2015, 88, 1323-1330.
(39) S. Saito, “Synthesis of interlocked compounds utilizing the catalytic activity of macrocyclic phenanthroline–Cu complexes” ;
J. Incl. Phenom. Macrocycl. Chem. 2015, 82, 437-451.
(38) Y. Yamashita, Y. Mutoh, R. Yamasaki, T. Kasama, S. Saito, “Synthesis of [3]Rotaxanes that Utilize the Catalytic Activity of a Macrocyclic Phenanthroline-Cu Complex: Remarkable Effect of the Length of the Axle Precursor” ;
Chem. Eur. J. 2015, 21(10), 2139-2145.
2014
(37)T. Shimizu, S. Koya, R. Yamasaki, Y. Mutoh, I. Azumaya, K. Katagiri, S. Saito, “Acid-Mediated Ring-Expansion Reaction of N-Aryl-2-vinylazetidines: Synthesis and Unanticipated Reactivity of Tetrahydrobenzazocines” ;
J. Org. Chem. 2014, 79(10), 4367-4377.
(36)R. Hayashi, K. Wakatsuki, R. Yamasaki, Y. Mutoh, T. Kasama, S. Saito, “Synthesis of rotacatenanes by the combination of Cu-mediated threading reaction and the template method: the dual role of one ligand” ;
Chem. Commun. 2014, 50, 204-206.
2013
(35)K. Ugajin, E. Takahashi, R. Yamasaki, Y. Mutoh, T. Kasama, and S. Saito, “Synthesis of [2]Rotaxanes by the Copper-Mediated Threading Reactions of Aryl Iodides with Alkynes”;
Org. Lett. 2013, 15, 2684-2687.
(34)R. Yamasaki, K. Kato, D. Hanitani, Y. Mutoh, and S. Saito, “Synthesis of monocyclic nine-membered compounds by the [4+3+2] cycloaddition-bond cleavage strategy”;
Tetrahedron Lett. 2013, 54, 3507-3509.
(33)S. Saito, E. Takahashi, K. Wakatsuki, K. Inoue, T. Orikasa, K. Sakai, R. Yamasaki, Y. Mutoh, and T. Kasama, “Synthesis of Large [2]Rotaxanes. The Relationship between the Size of the Blocking Group and the Stability of the Rotaxane”;
J. Org. Chem. 2013, 78, 3553-3560.
(32)R. Yamasaki, M. Ohashi, K. Maeda, T. Kitamura, M. Nakagawa, K. Kato, T. Fujita, R. Kamura, K. Kinoshita, H. Masu, I. Azumaya, S. Ogoshi, and S. Saito, "Ni-Catalyzed [4+3+2] Cycloaddition of Ethyl Cyclopropylideneacetate and Dienynes: Scope and Mechanistic Insights";
Chem. Eur. J. 2013, 19, 3415-3425.
2012
(31)S. Saito, T. Kobayashi, T. Makino, H. Yamaguchi, H. Muto, I. Azumaya, K. Katagiri, and R. Yamasaki, "Synthesis and structure of bidentate NHC-metal complexes with xanthene skeleton: the formation of cis and trans complexes”;
Tetrahedron 2012, 51, 8931-8936.
(30)T. Aoki, S. Koya, R. Yamasaki, and S. Saito, “Cycloaddition Reaction of 2-Vinylazetidines with Benzyne: A Facile Access to 1-Benzazocine Derivatives”;
Org. Lett. 2012, 14, 4506-4509.
(29)R. Yamasaki, H. Ikeda, H. Masu, I. Azumaya, and S. Saito, “Synthesis and properties of phenylogous amides”
Tetrahedron 2012, 51, 8450-8456.
(28)E. Kanno, K. Yamanoi, S. Koya, I. Azumaya, H. Masu, R. Yamasaki, and S. Saito, “[5 + 2] Cycloaddition Reaction of 2-Vinylaziridines and Sulfonyl Isocyanates. Synthesis of Seven-Membered Cyclic Ureas”;
J. Org. Chem. 2012, 77, 2142-2148.
2011
(27)R. Yamasaki, A. Shigeto, S. Saito, “Preparation of Shape-Persistent Macrocycles with a Single Pyridine Unit by Double Cross-Coupling Reactions of Aryl Bromides and Alkynes”;
J. Org. Chem. 2011, 76, 10299-10305.
(26)S. Saito, M. Saika, R. Yamasaki, I. Azumaya, H. Masu, “Synthesis and Structure of Dinuclear Silver(I) and Palladium(II) Complexes of 2,7-Bis(methylene)naphthalene-Bridged Bis-N-Heterocyclic Carbene Ligands”;
Organometallics 2011, 30, 1366-1373.
2010
(25)T. Makino, R. Yamasaki, I. Azumaya, H. Masu, and S. Saito, “Synthesis and Characterization of Silver and Palladium Complexes with Xanthene Based N-Heterocyclic Carbene-Oxazoline Ligands”;
Organometallics 2010, 29 (23), 6291-6297.
(24)S. Saito, T. Yoshizawa, S. Ishigami, R. Yamasaki, “Ring expansion reactions of ethyl cyclopropylideneacetate and benzosilacyclobutenes: formal σ bond cross metathesis.”;
Tetrahedron Lett. 2010, 51, 6028-6030.
(23)S. Saito, K. Maeda, R. Yamasaki, T. Kitamura, M. Nakagawa, K. Kato, I. Azumaya, and H. Masu, “Synthesis of Nine-membered Carbocycles by the [4 + 3 + 2] Cycloaddition Reaction of Ethyl Cyclopropylideneacetate and Dienynes”;
Angew. Chem. Int. Ed. 2010, 49, 1830-1833.
(22)R. Yamasaki, N. Terashima, I. Sotome, S. Komagawa and S. Saito, “Nickel-Catalyzed [3 + 2 + 2] Cycloaddition of Ethyl Cyclopropylideneacetate and Heteroatom-substituted Alkynes; Application to Selective Three-component Reaction with 1,3-Diynes.”
;
J. Org. Chem. 2010, 75, 480-483.
2009
(21)S. Koya, K. Yamanoi, R. Yamasaki, I. Azumaya, H. Masu, and S. Saito, “Selective Synthesis of Eight-membered Cyclic Ureas by the [6+2] Cycloaddition Reaction of 2-Vinylazetidines and Electron-Deficient Isocyanates”
;
Org. Lett. 2009, 11, 5438-5441.
(20)Y. Fukusaki, J. Miyazaki, I. Azumaya, K. Katagiri, S. Komagawa, R. Yamasaki, and S. Saito, “Thermal and catalytic isomerization of exomethylenecycloheptadienes. Experimental and theoretical studies”
;
Tetrahedron 2009, 65, 10631-10636.
(19)S. Komagawa, K. Takeuchi, I. Sotome, I. Azumaya, H. Masu, R. Yamasaki, and S. Saito, “Synthesis of Vinylcycloheptadienes by the Nickel-Catalyzed Three-Component [3+2+2] Cocyclization. Application to the Synthesis of Polycyclic Compounds”
;
J. Org. Chem. 2009, 79, 3323-3329.
(18) N. Watarai, H. Kawasaki, I. Azumaya, R. Yamasaki, and S. Saito, “Synthesis, structure and catalytic activity of macrocyclic NHC Pd pincer complexes”
;
Heterocycles 2009, 79, 531-548.
(17) Y. Sato, R. Yamasaki and S. Saito, “Synthesis of [2]Catenanes by the Reactions Mediated by Macrocyclic Copper Complexes.”
;
Angew. Chem. Int. Ed. 2009, 48, 504-507.
(16) R. Yamasaki, I. Sotome, S. Komagawa, I. Azumaya, H. Masu, and S. Saito, “Ni-catalyzed [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and 1,3-diynes. Application to the three-component cycloaddition.”
;
Tetrahedron Lett. 2009, 50, 1143-1145.
2008
(15) T. Makino, H. Masu, K. Katagiri, R. Yamasaki, Isao Azumaya, and S. Saito, “Synthesis, Structure, and Solvent-Induced Spontaneous Homochiral Assembly of Bidentate Bis(N,N’-diaryl-N-heterocyclic Carbene)-Palladium Complexes”
;
Eur. J. Inorg. Chem. 2008, 31, 4861-4865.
(14) Y. Nakatani, Y. Koizumi, R. Yamasaki, and S. Saito, “Copper-Catalyzed Synthesis of Esters from Ketones. Alkyl Group as a Leaving Group”
;
Org. Lett. 2008, 10, 2067-2070.
(13) T. Makino, R. Yamasaki, and S. Saito, “Concise Synthesis of Diborylxanthenes”;
Synthesis 2008, 72, 859-864.
2007
(12) S. Saito, S. Komagawa, I. Azumaya, and M. Masuda, “Nickel-Catalyzed Intermolecular [3 + 2 + 2] Cocyclization of Ethyl Cyclopropylideneacetate and Alkynes. Synthesis of Seven-Membered Carbocycles”;
J. Org. Chem. 2007, 72, 9114-9120.
(11) S. Saito, H. Yamaguchi, H. Muto and T. Makino, “First Synthesis of Bidentate NHC-Pd Complexes with Anthracene and Xanthene Skeletons”;
Tetrahedron Lett. 2007, 48, 7498-7501.
(10) K. Maeda and S. Saito, “Nickel-catalyzed [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and diynes. Synthesis of 7,6- and 7,5-fused bicyclic compounds”;
Tetrahedron Lett. 2007, 48, 3173-3176.
(9) S. Saito and K. Takeuchi, "Nickel-catalyzed [4 + 3] cycloaddition of ethyl cyclopropylideneacetate and 1,3-dienes"
Tetrahedron Lett. 2007, 48, 595-598.
2006
(8) S. Saito, E. Takahashi and K. Nakazono, "Synthesis of [2]Rotaxanes by the Catalytic Reactions of a Macrocyclic Copper Complex"
Org. Lett. 2006, 8, 5133-5136.
(7) S. Saito, K. Nakazono and E. Takahashi, "Template Synthesis of [2]Rotaxanes with Large Ring Components and Tris(biphenyl)methyl Group as the Blocking Group. The Relationship between the Ring Size and the Stability of the Rotaxanes"
J. Org. Chem. 2006, 71, 7477-7480.
(6) S. Komagawa and S. Saito "Nickel-Catalyzed Three-Component [3 + 2 + 2] Cocyclization of Ethyl Cyclopropylideneacetate and Alkynes. Selective Synthesis of Multisubstituted Cycloheptadienes"
Angew. Chem. Int. Ed. 2006, 45, 2446-2449.
(5) T. Munegumi, I. Azumaya, T. Kato, H. Masu, and S. Saito, "[3+2] Cross-Coupling Reactions of Aziridines with Isocyanates Catalyzed by Nickel(II) Iodide"
Org. Lett. 2006, 8, 379-382.
2005
(4) S. Saito, K. Takeuchi, T. Mise, and Y. Wakatsuki, "Ruthenium-catalyzed
cycloisomerization of 1,1,2,2,-tetramethyl-1,2-divinyldisilane. Selective
formation of a five-memberd sylacycle"
J. Organometallic. Chem. 2005, 690, 3451-3455.
(3) S. Saito and Y. Koizumi, "“Nickel(II) iodide”;
Tetrahedron Lett. 2005, 4715-4717.
(2) S. Saito, N. Dobashi, and Y. Wakatsuki, “Ruthenium-Catalyzed Hydrative
Dimerization of Allenes”
Chem. Lett. 2005, 34, 504-505.
2004
(1) S. Saito, M. Masuda, S. Komagawa, "Nickel-Catalyzed Intermolecular [3 + 2 + 2] Cocyclization of Ethyl
Cyclopropylideneacetate and Alkynes"
J. Am. Chem. Soc., 2004, 126, 10540-10541.
(11) Rashid, S.; Yoshigoe, Y.; Saito, S., "Phenanthroline based rotaxanes: recent developments in syntheses and applications."
RSC Advances 2022, 12(18), 11318-11344
(10) Mutoh, Y.; Yamamoto, K.; Mohara, Y.; Saito, S., "(Z)-Selective Hydrosilylation and Hydroboration of Terminal Alkynes Enabled by Ruthenium Complexes with an N-Heterocyclic Carbene Ligand"
Chem. Rec. 2021, 21, 1-14
(9) Mutoh, Y.; Ishii, Y.; Saito, S., "Direct Formation of Disubstituted Vinylidenes from Internal Alkynes at Group 8 Metal Complexes and its Application to Organic Synthesis"
Journal of Synthetic Organic Chemistry, Japan 2020, 78 (7), 691-702 (in Japanese)
(8) Yamazaki, Y.; Mutoh, Y.; Saito, S., "Synthesis of Interlocked Compounds by Utilizing Bond-forming Reactions Mediated by Macrocyclic Phenanthroline-Cu Complexes"
Chem. Lett. 2017, 46 (7), 904-912.
(7) Saito, S.; Katamura, T.; Mutoh, Y., "Synthesis of N-Heterocycles by the Ring Expansion Reactions of Aziridines and Azetidines"
Journal of Synthetic Organic Chemistry, Japan 2017, 75 (4), 340-348 (in Japanese).
(6) Florencio Zaragoza Dorwald (著)、齊藤隆夫 (訳)、斎藤慎一 (訳),
「有機合成の落とし穴-失敗例から学ぶ成功への近道」
丸善, 2009, ISBN-13: 978-4621080665.
(5) S. Komagawa, R. Yamasaki, and S. Saito, "Efficient Synthesis of Seven-membered Rings by the Nickel-catalyzed Cycloaddition Reactions"
Journal of Synthetic Organic Chemistry, Japan (Yuki Gosei Kagaku Kyokaishi), 2008, 66(10), 974-982 (in Japanese).
(4) K. Yamanoi and S. Saito, "Nickel(II) iodide"
Paquette, L. A. Ed.; e-EROS Encyclopedia of Reagents for Organic Synthesis, Wiley, New York, 2008.
(3) S. Saito, "Development of Novel Nickel- and Palladium-catalyzed Cycloaddition Reactions which Proceed with High Atom Economy" (in Japanese)
Yakugaku Zasshi 2005, 125(10), 771-784.
(2) S. Saito, "Development of New Cycloaddition Reactions Based on the Unique Reactivity of Unsaturated Hydrocarbons"
Chem. Pharm. Bull. 2005, 53(9), 1069-1076.
(1) S. Saito, "Cyclooligomerization and Cycloisomerization of Alkenes and Alkynes"
Tamaru Y. Ed.Modern Organonickel Chemistry, Wiley-VCH, New York, 2005; pp171-204.