Research Subjects in Shinichi Saito Group
1. Synthesis of Interlocked Compounds by New Methods
Interlocked compounds such as rotaxanes and catenanes are very attractive coumpounds.
We are developing new methods for the synthesis of interlocked compounds utilizing transition-metal mediated reactions.
We are also studying the dynamic behavior of these molecules.
Representative Publications
S. Saito, E. Takahashi and K. Nakazono,
"Synthesis of [2]Rotaxanes by the Catalytic Reactions of a Macrocyclic
Copper Complex"
Org. Lett. 2006, 8, 5133-5136.
Y. Sato, R. Yamasaki and S. Saito,
"Synthesis of [2]Catenanes by the Reactions Mediated by Macrocyclic Copper Complexes."
Angew. Chem. Int. Ed. 2009, 48, 504-507.
Y. Matsuoka, Y. Mutoh, T. Kasama, I. Azumaya, S. Kikkawa, T. Kasama, S. Saito,
"Synthesis and Shuttling Behavior of [2]Rotaxanes with a Pyrrole Moiety."
J. Org. Chem.
2016
, 3479-3487.
(ACS Editor's Choice and Featured Article)
CLICK HERE! Selected as the Front Cover
Y. Yamashita, Y. Saito, S. Kikkawa, Y. Mutoh, S. Hosoya, I. Azumaya S. Saito,
"Evaluation of the Steric Bulk of Substituents Utilizing the Shuttling Behavior of [2]Rotaxanes with N-Arylpyrrole Moieties."
Eur. J. Org. Chem.
2019
, 21
, 3412-3420.
CLICK HERE! Selected as the Cover Picture
2. Development of Novel Reactions with High Atom Economy
We are developing useful addition reactions and ring expansion reactions.
These reactions provide valuable compounds such as medium-sized cyclic compounds and organoboron compounds.
Many of these reactions proceeded with high atom economy.
Representative Publications
S. Saito, M. Masuda, S. Komagawa,
"Nickel-Catalyzed Intermolecular [3 + 2 + 2] Cocyclization of Ethyl Cyclopropylideneacetate and Alkynes"
J. Am. Chem. Soc.
2004
, 126
, 10540-10541.
S. Saito, K. Maeda, R. Yamasaki, T. Kitamura, M. Nakagawa, K. Kato, I. Azumaya, and H. Masu,
"Synthesis of Nine-membered Carbocycles by the [4 + 3 + 2] Cycloaddition Reaction of Ethyl Cyclopropylideneacetate and Dienynes"
Angew. Chem. Int. Ed.
2010
, 49
, 1830-1833.
T. Katamura, T. Shimizu, Y. Mutoh, S. Saito,
"Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction"
Org. Lett.
2017
, 19
, 266-269.
Y. Mutoh, K. Yamamoto, and S. Saito,
"Suzuki?Miyaura Cross-Coupling of 1,8-Diaminonaphthalene (dan)-Protected Arylboronic Acids"
ACS Catalysis
2020
, 10
, 352-357.
3. Organic reaction chemistry as a platform for interdisciplinary research in life sciences.
We investigate organic reaction chemistry at a fundamental level to develop methodologies applicable to biology, pharmaceuticals, and biotechnology.
