| Back | ||
 |
川崎 常臣 (Tsuneomi KAWASAKI) 東京理科大学 講師 総合研究機構（理学部応用化学科併任） Research Institute for Science and Technology (Department of Applied Chemistry) |
|
| Contact | Adress | 〒162-8601東京都新宿区神楽坂1-3 東京理科大学理学部応用化学科 |
| Tel | +81-3-3260-4272 (ext. 5792) | |
| Fax | +81-3-5261-4631 | |
| tkawa(a)rs.kagu.tus.ac.jp [change (a) to @] | ||
| 学歴 | 1999年 | 東京大学農学部卒業 |
| 2001年 | 東京大学大学院農学生命科学研究科修士課程修了 | |
| 2004年 | 東京大学大学院農学生命科学研究科博士課程修了（北原武教授） | |
| 職歴 | 2001年 | 理化学研究所ジュニア・リサーチ・アソシエイト(2004年3月まで） |
| 2004年 | 東京理科大学理学部応用化学科助手（硤合憲三教授） | |
| 2007年 | 東京理科大学理学部応用化学科助教 | |
| 2009年 | 東京理科大学総合研究機構講師 （理学部応用化学科併任） | |
| 学位 | 博士（農学）「生物活性を有する複素環天然物の合成研究」 | |
| 受賞 | 2004年 | 有機合成化学協会日産化学工業研究企画賞 「不斉自己増殖するキラルモノマーおよびキラルデンドリマーの開発」 |
| 2006年 | International Molecular Chirality Conference in Toyama (MC2006) Poster
Award “Spontaneous asymmetric autocatalysis in the presence of achiral amine” |
|
| 2007年 | シンポジウム「モレキュラー・キラリティー2007」ポスター最優秀賞 「炭素同位体置換キラル化合物を不斉開始剤とする不斉自己触媒反応」 |
|
| 2007年 | 英国王立化学会Organic & Biomolecular Chemistry Poster Award (International
Conference “Chirality at the Nanoscale 2007”) “Discrimination of carbon isotope chirality by asymmetric autocatalysis with amplification of enantiomeric excess” http://www.rsc.org/Publishing/Journals/OB/News/2007/October/OBC_Poster_Prize.asp |
|
| 2008年 | 4th Symposium on Chemical Approaches to Chirality Poster Award "Chiral Discrimination of Carbon Isotope Substituted Chiral Compounds by Asymmetric Autocatalysis" |
|
| 2008年 | 15th International Conference on the Origin of Life (Florence ISSOL’08)
Poster Award "Chiral crystals of achiral biological compounds as an origin of homochirality of biomolecules in conjunction with asymmetric autocatalysis" |
|
| 2009年 | 第２３回若い世代の特別講演会（日本化学会第８９春季年会）特別講演者に選出 「アキラル化合物の不斉結晶化によるキラリティーの発現と不斉自己触媒による高エナンチオ選択的不斉合成反応」 |
|
| 2010年 | 第５９回日本化学会進歩賞（平成21年度） 「炭素同位体キラル化合物による不斉誘導現象の発見と超高感度不斉認識」 |
|
| 2010年 | 文部科学大臣表彰若手科学者賞（平成２２年度） 「炭素同位体不斉誘起現象の発見と高感度不斉認識の研究」 |
|
| 2011年 | Banyu Chemist Award (BCA 2011) "Asymmetric Synthesis Induced by Carbon and Oxygen Isotopomers and Highly Sensitive Chiral Discrimination by Using Asymmetric Autocatalysis." |
|
| 発表論文 | (1) | Total synthesis of (±)-cocculolidine. Kawasaki, T.; Onoda, N.; Watanabe, H.; Kitahara, T. Tetrahedron Lett. 2001, 42, 8003-8006. [Link] |
| (2) | Asymmetric autocatalysis initiated by chiral ephedrine immobilized on silica gel in a diisopropylzinc addition to pyrimidine-5-carbaldehyde. Sato, I.; Shimizu, M.; Kawasaki, T.; Soai, K. Bull. Chem. Soc. Jpn. 2004, 77, 1587-1588. |
|
| (3) | Enantioselective synthesis of substituted 3-quinolyl alkanols and their application to asymmetric autocatalysis. Sato, I.; Nakao, T.; Sugie, R.; Kawasaki, T.; Soai, K. Synthesis 2004, 1419-1428. |
|
| (4) | Enantioselective synthesis induced by chiral organic-inorganic hybrid silsesquioxane in conjunction with asymmetric autocatalysis. Kawasaki, T.; Ishikawa, K.; Sekibata, H.; Sato, I.; Soai, K. Tetrahedron Lett. 2004, 45, 7939-7941. |
|
| (5) | Enantioselective synthesis induced by chiral epoxides in conjunction with asymmetric autocatalysis. Kawasaki, T.; Shimizu, T.; Suzuki, K.; Sato, I.; Soai, K. Tetrahedron: Asymmetry 2004, 15, 3699-3701. |
|
| (6) | Asymmetric amplification using chiral cocrystals formed from achiral organic molecules by asymmetric autocatalysis. Kawasaki, T.; Jo, K.; Igarashi, H.; Sato, I.; Nagano, M.; Koshima, H.; Soai, K. Angew. Chem. Int. Ed. 2005, 44, 2774-2777. |
|
| (7) | Enantioselective synthesis of near enantiopure compound by asymmetric autocatalysis triggered by asymmetric photolysis with circularly polarized light. Kawasaki, T.; Sato, M.; Ishiguro, S.; Saito, T.; Morishita, Y.; Sato, I.; Nishino, H.; Inoue, Y.; Soai, K. J. Am. Chem. Soc. 2005, 127, 3274-3275. |
|
| (8) | Small amounts of achiral beta-amino alcohols reverse the enantioselectivity of chiral catalysts in cooperative asymmetric autocatalysis. Lutz, F.; Igarashi, T.; Kawasaki, T.; Soai, K. J. Am. Chem. Soc. 2005, 127, 12206-12207. |
|
| (9) | Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis. Tokai, T.; Koshino, H.; Kawasaki, T.; Igawa, T.; Suzuki, Y.; Sato, M.; Fujimura, M.; Eizuka, T.; Watanabe, H.; Kitahara, T.; Ohta, K.; Shibata, T.; Kudo, T.; Inoue, H.; Yamaguchi, I.; Kimura, M. FEMS Microbiol. Lett. 2005, 251, 193-201. |
|
| (10) | Asymmetric autocatalysis of a ferrocene-containing chiral compound with amplification of chirality. Lutz, F.; Kawasaki, T.; Soai, K. Tetrahedron: Asymmetry 2006, 17, 486-490. |
|
| (11) | Enantioselective synthesis mediated by chiral crystal of achiral hippuric acid in conjunction with asymmetric autocatalysis. Kawasaki, T.; Suzuki, K.; Hatase, K.; Otsuka, M.; Koshima, H.; Soai, K. Chem. Commun. 2006, 1869-1871. |
|
| (12) | Chiral discrimination of cryptochiral saturated quaternary and tertiary hydrocarbons by asymmetric autocatalysis. Kawasaki, T.; Tanaka, H.; Tsutsumi, T.; Kasahara, T.; Sato, I.; Soai, K. J. Am. Chem. Soc. 2006, 128, 6032-6033. |
|
| (13) | Spontaneous absolute asymmetric synthesis in the presence of achiral silica gel in conjunction with asymmetric autocatalysis. Kawasaki, T.; Suzuki, K.; Shimizu, M.; Ishikawa, K.; Soai, K. Chirality 2006, 18, 479-482. |
|
| (14) | Asymmetric autocatalysis and the origin of homochirality. Soai, K.; Kawasaki, T. Shokubai (Catalysts & Catalysis) 2006, 48, 346-352. |
|
| (15) | Discovery of asymmetric autocatalysis with amplification of chirality and its implications in chiral homogeneity of biomolecules. Soai, K.; Kawasaki, T. Chirality 2006, 18, 469-478. |
|
| (16) | Enantioselective synthesis induced by tetrathia-[7]-helicenes in conjunction with asymmetric autocatalysis. Kawasaki, T.; Suzuki, K.; Licandro, E.; Bossi, A.; Maiorana, S.; Soai, K. Tetrahedron: Asymmetry 2006, 17, 2050-2053. |
|
| (17) | The distribution of chiral asymmetry in meteorites: an investigation using asymmetric autocatalytic chiral sensors. Kawasaki, T.; Hatase, K.; Fujii, Y.; Jo, K.; Soai, K.; Pizzarello, S. Geochim. Cosmochim. Acta 2006, 70, 5395-5402. |
|
| (18) | Asymmetric autocatalysis induced by octahedral tris(acetylacetonato)chromium(III) complex as a homogeneous chiral initiator. Kawasaki, T.; Omine, T.; Sato, M.; Morishita, Y.; Soai, K. Chem. Lett. 2007, 36, 30-31. |
|
| (19) | Determination of absolute configurations of amino acids by asymmetric autocatalysis of 2-alkynylpyrimidyl alkanol as a chiral sensor. Sato, I.; Ohgo, Y.; Igarashi, H.; Nishiyama, D.; Kawasaki, T.; Soai, K. J. Organomet. Chem. 2007, 692, 1783–1787. |
|
| (20) | Chiral secondary alcohol-induced asymmetric autocatalysis: correlation
between the absolute configuration of the chiral initiators and the product Takanori Shibata, Kimiko Iwahashi, Tsuneomi Kawasaki and Kenso Soai Tetrahedron: Asymmetry 2007, 18, 1759-1762. |
|
| (21) | Achiral nucleobase cytosine acts as an origin of homochirality of biomolecules in conjunction with asymmetric autocatalysis. Kawasaki, T.; Suzuki, K.; Hakoda, Y.; Soai, K. Angew. Chem. Int. Ed. 2008, 47, 496-499. |
|
| (22) | Mechanistic Insights in the Reversal of Enantioselectivity of Chiral Catalysts
by Achiral Catalysts in Asymmetric Autocatalysis Francois Lutz, Takashi Igarashi, Tomoyuki Kinoshita, Mai Asahina, Koichi Tsukiyama, Tsuneomi Kawasaki, Kenso Soai J. Am. Chem. Soc. 2008, 130, 2956-2958. |
|
| (23) | Chemical Approaches to the Elucidation of the Origins of Homochirality
by Asymmetric Autocatalysis. Kenso Soai, Tsuneomi Kawasaki Fine Chemicals, 2008, 37, 5-16. |
|
| (24) | Enantioselective Synthesis Utilizing Enantiomorphous Organic Crystal of
Achiral Benzils as a Source of Chirality in Asymmetric Autocatalysis. Kawasaki, T.; Harada, Y.; Suzuki, K.; Tobita, T.; Florini, N.; Palyi, G.; Soai, K. Org. Lett. 2008, 10, 4085-4088. |
|
| (25) | Highly enantioselective asymmetric autocatalysis using chiral ruthenium
complex-ion-exchanged synthetic hectorite as a chiral initiator. T. Kawasaki, T. Omine, K. Suzuki, H. Sato, A. Yamagishi, K. Soai Org. Biomol. Chem. 2009, 7, 1073-1075. [Hot Article] [Cover Picture] |
|
| (26) | Asymmetric Autocatalysis Triggered by Carbon Isotope (13C/12C) Chirality T. Kawasaki, Y. Matsumura, T. Tsutsumi, K. Suzuki, M. Ito, K. Soai Science 2009, 324, 492-495 [electronic reprint is available]. Picked up: C&EN 2009, 87(13), 29. [March 30, 2009; Science & Technology Concentrates] Synfacts 2009, 2009(08), 0760. Nature Chemistry [Research Highlights] Synform 2009/06. |
|
| (27) | Asymmetric Autocatalysis Induced by Meteoritic Amino Acids with Hydrogen
Isotope Chirality T. Kawasaki, M. Shimizu, D. Nishiyama, M. Ito, H. Ozawa, K. Soai Chem. Commun. 2009, 4396-4398 (Hot Article). PDF: Open science. Picked up: Highlights in Chemical Science 2009, 6(8), C60. 2009 ChemComm web theme issue: "Selective Catalysis for Organic Synthesis" |
|
| (28) | Discrimination of Cryptochirality in Chiral Isotactic Polystyrene by Asymmetric
Autocatalysis T. Kawasaki, C. Hohberger, Y. Araki, K. Hatase, K. Beckerle, J. Okuda, K. Soai Chem. Commun. 2009, 5621-5623. PDF: Open science |
|
| (29) | Asymmetric Autocatalysis Induced by Chiral Crystals of Achiral Tetraphenylethylenes T. Kawasaki, M. Nakaoda, N. Kaito, T. Sasagawa, K. Soai Orig. Life Evol. Biosph. 2010, 40, 65-78. |
|
| (30) | Generation of Absolute Controlled Crystal Chirality by the Removal of Crystal
Water from Achiral Crystal of Nucleobase Cytosine T. Kawasaki, Y. Hakoda, H. Mineki, K. Suzuki and K. Soai J. Am. Chem. Soc. 2010, 132, 2874-2875. PDF: ACS AuthorChoice. |
|
| (31) | Spontaneous absolute asymmetric synthesis promoted by achiral amines in
conjunction with asymmetric autocatalysis. K. Suzuki, K. Hatase, D. Nishiyama, T. Kawasaki and K. Soai J. Systems Chem. 2010, 1, 5. |
|
| (32) | Enantioselective Synthesis induced by Compounds with Chirality Arising from Partially Deuterated Methyl Groups in Conjunction with Asymmetric Autocatalysis. Kawasaki, T.; Ozawa, H.; Ito, M.; Soai, K. Chem. Lett. 2011, 40, 320-321. [Editor's Choice] |
|
| (33) | Reversal Phenomenon of Enantioface Selectivity by the Cooperative Operation
of Two Chiral Catalysts. T. Kawasaki, Y. Wakushima, M. Asahina, K. Shiozawa, T. Kinoshita, F. Lutz and K. Soai Chem. Commun. 2011, 47, 5277-5279. |
|
| (34) | Enantioselective Synthesis Induced by Chiral Crystal Composed of DL-Serine
in Conjunction with Asymmetric Autocatalysis T. Kawasaki, T. Sasagawa, K. Shiozawa, M. Uchida, K. Suzuki and K. Soai Org. Lett. 2011, 13, 2361-2363. |
|
| (35) | Enantioselective C-C Bond Formation Arising from Oriented Prochirality
of Achiral Aldehyde at the Single Crystal Face by the Treatment of Dialkylzinc
Vapor Tsuneomi Kawasaki, Sayaka Kamimura, Ai Amihara, Kenta Suzuki, Kenso Soai Angew. Chem. 2011, 123, 6928-6930. Angew. Chem. Int. Ed. 2011, 50, 6796-6798. PDF: Open Access |
|
| (36) | Asymmetric Autocatalysis: Triggered by Chiral Isotopomer Arising from Oxygen
Isotope Substitution Tsuneomi Kawasaki, Yasushi Okano, Etsuharu Suzuki, Shizuka Takano, Shotaro Oji, Kenso Soai Angew. Chem. 2011, 123, 8281-8283. Angew. Chem. Int. Ed. 2011, 50, 8131-8133. |
|
| 総説/著書 | (1) | Enantioselective addition of organozinc compounds. Soai, K.; Sato, I.; Kawasaki, T. in The Chemistry of Organozinc Compounds, Ed. by Rappoprt, Z., Marek, I. John Wiley & Sons, (2007) pp. 555-593. |
| (2) | Asymetric Autocatalysis and Its Implications in the Origin of Chiral Homogeneity of Biomolecules. Soai, K.; Kawasaki, T. in Asymmetric Synthesis -The Essentials, Ed. by Christmann, M.; Brase, S. Wiley-VCH, (2007) pp. 212-216. |
|
| (3) | Asymetric Autocatalysis with Amplification of Chirality and Origin of Chiral Homogeneity of Biomolecules Soai, K.; Kawasaki, T.; Sato, I. in New Frontiers in Asymmetric Catalysis, Ed. by Mikami, K.; Lautens, M., Wiley-Interscience, (2007) pp. 259-274. |
|
| (4) | S-Diphenyl(1-methylpyrrolidin-2-yl)methanol Soai, K.; Kawasaki, T. in Electronic Encyclopedia of Reagents for Organic Synthesis, Ed. by Paquette, L.: Fuchs, P.: Molander, G., John Wiley & Sons, Ltd, (2007). |
|
| (5) | Asymmetric autocatalysis with amplification of chirality. Soai, K.; Kawasaki, T. Top. Curr. Chem. 2008, 284, 1-33. Springer Berlin / Heidelberg |
|
| (6) |
Symmetry Breaking in Asymmetric Autocatalysis of Pyrimidyl Alkanol |
|
| (7) | 不斉自己触媒反応を用いて不斉の起源に迫る Soai, K.; Kawasaki, T. 化学と教育 (Chemistry and Education) 2008, 56, 384-385. |
|
| (8) | Asymmetric Autocatalysis of Pyrimidyl Alkanol Using an Organozinc Reagent Kenso Soai, Tsuneomi Kawasaki In Organometallic Chirality. Ed. by Palyi, G., Zucchi, C., Caglioti, L., Mucchi Editore, Modena, Chap. 6, pp. 107-125 (2008). |
|
| (9) | 炭素同位体（13C/12C）置換キラル化合物による不斉合成―不斉自己触媒反応を用いて― Kawasaki, T. 化学と工業 (Chemistry & Chemical Industry) 2009, 62(8), 898-900. 「飛翔する若手研究者」欄 |
|
| (10) | 解説 不斉現象に新事実 炭素同位体で光学活性体に偏りが生じる！ Soai, K.; Kawasaki, T. 化学 (Chemistry) 2009, 64(10), 38-43. |
|
| (11) | Kenso Soai, Tsuneomi Kawasaki Organometallic News 2009, (1), 20-21. |
|
| (12) | 展望：同位体不斉が引き起こす不斉自己触媒反応－ホモキラリティーの起源としての同位体不斉－ Tsuneomi Kawasaki, Kenso Soai Isotope News 2009, Nov., (667), 2-6. |
|
| (13) | Amplification of chirality as a pathway to biological homochirality Tsuneomi Kawasaki and Kenso Soai J. Fluor. Chem. 2010, 131, 525-534. |
|
| (14) | Asymmetric autocatalysis. Automultiplication of Chiral Molecules Kenso Soai, Tsuneomi Kawasaki Chimica Oggi (Chemistry Today, supplement: Chiral Technologies) 2009, 27(6), 3-7. |
|
| (15) | Asymmetric Amplification and Autocatalysis Soai, K.; Kawasaki, T.; Shibata, T. in Catalytic Asymmetric Synthesis, Third Edition, Ed. by Ojima, I., John Wiley & Sons, Inc., Hoboken, New Jersey, Chap. 12, pp. 891-930 (2010). |
|
| (16) | アキラル化合物の結晶化によるキラリティー発生と キラル有機結晶を不斉源とする不斉自己触媒反応 川﨑常臣、硤合憲三 日本結晶学会誌, 2011, 53, 201-206. |
|
| (17) | キラル分子の不斉起源とホモキラリティーの謎に迫る 硤合憲三、川﨑常臣 化学 (Chemistry) 2011, 66(8), 49-53. |
|
| (18) | Asymmetric Induction Arising from Enantiomerically Enriched Carbon-13 Isotopomers
and Highly Sensitive Chiral Discrimination by Asymmetric Autocatalysis.
Tsuneomi Kawasaki, Kenso Soai Bull. Chem. Soc. Jpn. 2011, 84, 879-892. [PDF] |
|
| (19) | 右手と左手の化学—不斉自己触媒反応を用いる不斉の起源解明と高感度キラル認識— 川﨑常臣，硤合憲三 理大科学フォーラム, 2011, 印刷中. |
|
| 国際会議 口頭発表 |
(1) | Invited Lecture] 8th Symposium on Chemical Approaches to Chirality, December
1, 2010, Tokyo, Japan. "Chiral Discrimination of Carbon and Hydrogen Isotope Enantiomers by Asymmetric Autocatalysis" Tsuneomi Kawasaki, Kenta Suzuki, Yukari Matsumura, Masateru Ito, Hitomi Ozawa, Takayuki Tobita, Taisuke Sasagawa, Kenso Soai |
| (2) | [Keynote Lecture] 2nd International Symposium on the Soai Reaction and
Related Topic, Sept. 2010, Mocslad, Budapest, Hungary. "Recent Aspects of Asymmetric Autocatalysis" Tsuneomi Kawasaki, Kenso Soai |
|
| (3) | [Invited Lecture] 3rd Microsymposium on Asymmetric SynthesisWarsaw, Polish
Academy of Science Sept. 2010 "Asymmetric Autocatalysis Triggered by Carbon and Hydrogen Isotope Chirality" Tsuneomi Kawasaki, Kenta Suzuki, Takashi Tsutsumi, Yukari Matsumura, Takayuki Tobita, Masateru Ito, Hitomi Ozawa, Kenso Soai |
|
| (4) | [Invited Lecture] 2nd TUS International Collaboration Workshop -Joint Symposium
with International Industry-Academia-Government Collaboration-, Dec. 2008,
Tokyo, Japan. "Asymmetric Autocatalysis Induced by Chiral Crystals Composed of Achiral Organic and Inorganic Compounds as the Possible Route for the Origin and Evolution of Chirality " T. Kawasaki, K. Suzuki, Y. Araki, Y. Hakoda, Y. Harada, T. Tobita, K. Soai |
|
| (5) | Chirality 2007-19th International Symposium on Chirality (ISCD-19), July,
2007, San Diego, USA. “Discrimination of carbon isotope chirality by asymmetric autocatalysis with amplification of chirality” Kawasaki, T.; Tsutsumi, T.; Matsumura, Y.; Soai, K. |
|
| (6) | Chirality 2006-18th International Symposium on Chirality (ISCD-18), Jun, 2006, Busan, Korea. “Highly sensitive chiral discrimination of cryptochiral saturated quaternary hydrocarbons by asymmetric autocatalysis” Kawasaki, T.; Tsutsumi, T.; Matsumura, Y.; Soai, K. |
|
| (7) | International Molecular Chirality Conference in Toyama (MC2006), May, 2006, Toyama, Japan. “Asymmetric autocatalysis mediated by chiral crystals formed form achiral organic molecules” Kawasaki, T.; Tanaka, H.; Tsutsumi, T.; Kasahara, T.; Sato, I.; Soai, K |
|
| 国内会議 招待講演 |
(1) | [招待講演] 第28回千葉地域活動若手セミナー 2011年3月10日 東京理科大学野田キャンパス 炭素および水素同位体キラル化合物が引き起こす不斉自己触媒反応 |
| (2) | [招待講演] 日本農芸化学会 関東支部2010年度第2回支部例会シンポジウム「有機合成の可能性・生命現象を探る」 東京大学農学部・弥生講堂 2011年1月22日 炭素同位体キラル化合物による不斉誘起と不斉自己触媒による高感度不斉認識 |
|
| (3) | [依頼講演] 日本化学会第4回関東支部大会(2010) つくば市・筑波大学筑波キャンパス、2010年8月30日 「不斉自己触媒反応を用いるキラルセンシング」 川崎常臣・鈴木健太・堤隆志・松村友香里・伊藤真央・小澤瞳・峯木紘子・笹川泰介・硤合憲三 |
|
| (4) | [招待講演] 特定非営利活動法人科学知総合研究所（SKIL)第23回合同研究会 東京・東京大学武田先端知ビル、2010年8月27日 キラル化合物の高感度不斉認識ー不斉自己触媒反応を用いてー |
|
| (5) | [受賞講演] 日本化学会第90春季年会 東大阪・近畿大、2010年3月 (日)炭素同位体キラル化合物による不斉誘導現象の発見と超高感度不斉認識 (英)Asymmetric Induction Arising from Enantiomerically Enriched Carbon-13 Isotopomers and Highly Sensitive Chiral Discrimination |
|
| (6) | [招待講演] 錯体化学若手の会関東支部平成21年度第2回勉強会 東京・東京理科大学、2009年11月28日 「炭素同位体置換によるキラル化合物が引き起こす不斉自己触媒反応」 |
|
| (7) | [招待講演] 第２３回若い世代の特別講演会（日本化学会第８９春季年会） 船橋・日大工学部船橋キャンパス2009年3月 「アキラル化合物の不斉結晶化によるキラリティーの発現と不斉自己触媒による高エナンチオ選択的不斉合成反応」 |
|